I will describe several new, extremely efficient approaches to chiral discrimination and enantio-sensitive molecular manipulation, which take advantage of ultrafast electronic response [1,2]. One of them is based on the new concept of synthetic chiral light [3,4], which can be used to trigger bright nonlinear optical response in the molecule of a desired handedness while keeping its mirror twin dark in the same frequency range. The other is based on the new concept of geometric magnetism in photoionization of chiral molecules and leads to a new class of enantiosensitive observables in photoionization . Crucially, the emergence of these new observables is associated with ultrafast excitation of chiral electronic or vibronic currents prior to ionization and can be viewed as their unique signature.
 S Beaulieu et al, Photoexcitation circular dichroism in chiral molecules, Nature Physics 14 (5), 484 (2018)  AF Ordonez, O Smirnova, Generalized perspective on chiral measurements without magnetic interactions, Physical Review A 98 (6), 063428, 2018  D Ayuso et al, Synthetic chiral light for efficient control of chiral light–matter interaction, Nature Photonics 13 (12), 866-871, (2019)  D. Ayuso et al "Enantio-sensitive unidirectional light bending”, Nat Commun 12, 3951 (2021)  AF Ordonez, D Ayuso, P. Decleva, O Smirnova “Geometric magnetism and new enantio-sensitive observables in photoionization of chiral molecules” http://arxiv.org/abs/2106.14264